Overcoming immunosuppression in bone metastases
| Autor: | Francis J. Giles, Sarki A. Abdulkadir, Vinay Sagar, Benedito A. Carneiro, Ricardo Costa, Zachary Z. Reinstein, Sahithi Pamarthy |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Standard of care medicine.medical_treatment Antineoplastic Agents Bone Neoplasms Disease 03 medical and health sciences 0302 clinical medicine Prostate Neoplasms Internal medicine Tumor Microenvironment medicine Animals Humans Immunosuppression Therapy Tumor microenvironment business.industry Treatment options Bone metastasis Immunosuppression Cryoablation Hematology medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 117:114-127 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2017.05.004 |
| Popis: | Bone metastases are present in up to 70% of advanced prostate and breast cancers and occur at significant rates in a variety of other cancers. Bone metastases can be associated with significant morbidity. The establishment of bone metastasis activates several immunosuppressive mechanisms. Hence, understanding the tumor-bone microenvironment is crucial to inform the development of novel therapies. This review describes the current standard of care for patients with bone metastatic disease and novel treatment options targeting the microenvironment. Treatments reviewed include immunotherapies, cryoablation, and targeted therapies. Combinatorial treatment strategies including targeted therapies and immunotherapies show promise in pre-clinical and clinical studies to overcome the suppressive environment and improve treatment of bone metastases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect