Measures of Thyroid Function among Belarusian Children and Adolescents Exposed to Iodine-131 from the Accident at the Chernobyl Nuclear Plant

Autor:	Vasilina Yauseyenka, Irina Savasteeva, Kyoji Furukawa, Lydia B. Zablotska, Vladimir Drozdovitch, Kiyohiko Mabuchi, Eldar Nadyrov, Robert J. McConnell, Evgenia Ostroumova, Viktor Minenko, Alexander Rozhko, Sergey Petrenko, Olga Polyanskaya, George Romanov, Alexander Prokopovich, Alina V. Brenner, Maureen Hatch
Rok vydání:	2013
Předmět:	endocrine system medicine.medical_specialty Pediatrics Goiter endocrine system diseases Health Toxicology and Mutagenesis Chernobyl Autoimmune thyroiditis Thyroid peroxidase dose response Internal medicine medicine hyperthyroidism antithyroid antibodies thyroid gland biology business.industry Research Thyroid Public Health Environmental and Occupational Health autoimmune thyroiditis Odds ratio medicine.disease radioiodine Endocrinology medicine.anatomical_structure Cohort Chornobyl biology.protein hypothyroidism Thyroid function business Cohort study
Zdroj:	Environmental Health Perspectives
ISSN:	1552-9924 0091-6765
DOI:	10.1289/ehp.1205783
Popis:	Background: Thyroid dysfunction after exposure to low or moderate doses of radioactive iodine-131 (131I) at a young age is a public health concern. However, quantitative data are sparse concerning 131I-related risk of these common diseases. Objective: Our goal was to assess the prevalence of thyroid dysfunction in association with 131I exposure during childhood (≤ 18 years) due to fallout from the Chernobyl accident. Methods: We conducted a cross-sectional analysis of hypothyroidism, hyperthyroidism, autoimmune thyroiditis (AIT), serum concentrations of thyroid-stimulating hormone (TSH), and autoantibodies to thyroperoxidase (ATPO) in relation to measurement-based 131I dose estimates in a Belarusian cohort of 10,827 individuals screened for various thyroid diseases. Results: Mean age at exposure (± SD) was 8.2 ± 5.0 years. Mean (median) estimated 131I thyroid dose was 0.54 (0.23) Gy (range, 0.001–26.6 Gy). We found significant positive associations of 131I dose with hypothyroidism (mainly subclinical and antibody-negative) and serum TSH concentration. The excess odds ratio per 1 Gy for hypothyroidism was 0.34 (95% CI: 0.15, 0.62) and varied significantly by age at exposure and at examination, presence of goiter, and urban/rural residency. We found no evidence of positive associations with antibody-positive hypothyroidism, hyperthyroidism, AIT, or elevated ATPO. Conclusions: The association between 131I dose and hypothyroidism in the Belarusian cohort is consistent with that previously reported for a Ukrainian cohort and strengthens evidence of the effect of environmental 131I exposure during childhood on hypothyroidism, but not other thyroid outcomes.
Databáze:	OpenAIRE
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