Combined effect of Controlling Nutritional Status and Acute Kidney Injury on severe COVID-19 short-term outcomes
| Autor: | Abdelghani Bachir Cherif, S. Bennouar, Amel Kessira, Samia Abdi, Djamel-Eddine Bennouar |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Nutrition and Dietetics Multivariate analysis Coronavirus disease 2019 (COVID-19) mortalité à court terme 030309 nutrition & dietetics business.industry Endocrinology Diabetes and Metabolism Acute kidney injury COVID-19 CONUT score Renal function Nutritional status Acute Kidney Injury medicine.disease University hospital Article 03 medical and health sciences Malnutrition Internal medicine Relative risk Internal Medicine medicine business |
| Zdroj: | Nutrition Clinique et Me´tabolisme |
| ISSN: | 0985-0562 |
| DOI: | 10.1016/j.nupar.2021.03.001 |
| Popis: | Acute kidney injury (AKI) and malnutrition are two complications commonly reported in severe forms of COVID-19, their combined effect on short-term mortality is, however, not yet investigated. The objective of this study is to determine both their individual and combined effects on short-term prognosis.This is a prospective, uni-centric study, including 247 severe COVID-19 patients, admitted between April 25th and June 20th, 2020, at the University Hospital of Blida. AKI was defined according to the KDIGO-2012 guidelines. Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score. The association with in-hospital mortality was assessed using the Kaplan-Meier method and proportional Cox regression.Among the 247 severely affected COVID-19 patients included in this study, 34.4% developed AKI, 30.4 and 1.2%, respectively, had moderate and severe CONUT scores, 17.7% worsened and progressed to a critical state and 26.7% did not survive. Both AKI and CONUT score were significantly associated with mortality in a dose-response manner (pLog-Rank |
| Databáze: | OpenAIRE |
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