Induction of phenazine biosynthesis in cultures ofPseudomonas aeruginosaby L-N-(3-oxohexanoyl) homoserine lactone
| Autor: | Brian A.M. Rudd, Michael J. Dawson, Helen Bradshaw, David Noble, Paul Stead |
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| Rok vydání: | 1996 |
| Předmět: |
Microbiological Techniques
Gram-negative bacteria Phenazine Homoserine Microbial Sensitivity Tests Saccharomyces cerevisiae Biology medicine.disease_cause Microbiology Pheromones chemistry.chemical_compound 4-Butyrolactone Gram-Negative Bacteria Escherichia coli Genetics medicine Molecular Biology Chromatography High Pressure Liquid Dose-Response Relationship Drug Pseudomonas aeruginosa Pseudomonas biology.organism_classification Biochemistry chemistry Pseudomonadales Phenazines Bacteria Bacillus subtilis Pseudomonadaceae |
| Zdroj: | FEMS Microbiology Letters. 140:15-22 |
| ISSN: | 1574-6968 0378-1097 |
| Popis: | A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor L-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the production of phenazine metabolites was shown to be inducible in a dose-dependent manner. The production of phenazine-1-carboxamide increased over 50-fold compared to control cultures when supplemented with 200 micrograms/ml of the autoregulator. In addition, the production of an unidentified polar antibacterial substance by this strain increased with autoregulator concentration. |
| Databáze: | OpenAIRE |
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