Prognostic Impact of Clinicopathological Features and Expression of Biomarkers Related to F-18-FDG Uptake in Esophageal Cancer

Autor: Henk Groen, Kirill Pavlov, L. Schreurs, John T. M. Plukker, Jan Pruim, Bareld B. Pultrum, Harmen Hollema, Justin K. Smit
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Methods in Medicines evaluation & Outcomes research (M2O), Reproductive Origins of Adult Health and Disease (ROAHD), Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE)
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Pathology
STANDARDIZED UPTAKE VALUE
Esophageal Neoplasms
medicine.medical_treatment
Esophageal cancer
Gastroenterology
Immunoenzyme Techniques
Surgical oncology
Lymph node
Aged
80 and over
Middle Aged
Prognosis
Survival Rate
medicine.anatomical_structure
Oncology
Vascular endothelial growth factor C
Esophagectomy
Lymphatic Metastasis
Carcinoma
Squamous Cell
SURVIVAL
Female
SQUAMOUS-CELL CARCINOMA
Adult
medicine.medical_specialty
Standardized uptake value
Adenocarcinoma
POSITRON-EMISSION-TOMOGRAPHY
LUNG-CANCER
Fluorodeoxyglucose F18
Internal medicine
medicine
Biomarkers
Tumor
Humans
ROC CURVES
HYPOXIA-INDUCIBLE FACTOR-1-ALPHA
Lung cancer
FACTOR-C
Aged
Neoplasm Staging
Receiver operating characteristic
business.industry
HEXOKINASE-II
medicine.disease
Standardized uptake values
Positron-Emission Tomography
F-18-FDG-PET
ENDOTHELIAL GROWTH-FACTOR
Surgery
Radiopharmaceuticals
business
Biomarkers
Follow-Up Studies
Zdroj: Annals of Surgical Oncology, 21(12), 3751-3757. SPRINGER
ISSN: 1068-9265
DOI: 10.1245/s10434-014-3848-6
Popis: To analyze the association between pretreatment 18-F-fluoro-deoxyglucose (FDG) uptake and characteristics of aggressive tumor biology in predicting outcome in esophageal cancer (EC).Tumor FDG-uptake was measured by maximum standardized uptake values (SUVmax) in 47 patients undergoing esophagectomy with curative intent. ROC analyses were used to predict an optimal SUVmax cutoff for survival. Expression of hexokinase-II (HK-II), glucose transporter I (GLUT-I), hypoxia inducible factor-1 alpha (HIF-I alpha), vascular endothelial growth factor-C (VEGF-C), p53, and proliferative activity (Ki-67) were correlated with SUVmax values and clinicopathological characteristics.A SUVmax > 3.67 predicted a significantly lower disease-free survival (DFS) and distant recurrence-free survival (p = 0.022 and p = 0.005). High HK-II expression was correlated with reduced SUVmax values (p = 0.002) and was significantly higher in esophageal adenocarcinoma compared with squamous cell carcinoma (p = 0.005). Preoperative high FDG uptake in primary tumors was associated with nodal metastases (pN1; Spearman correlation 0.39, p = 0.01). We found no positive correlation between SUVmax and GLUT-1, HK-1, HIF-I alpha 1, VEGF-C, p53, and Ki-67 expression.High preoperative FDG-uptake strongly predicts poor survival outcome and is associated with lymph node metastases in EC patients. HK-II expression was related to SUVmax and DFS.
Databáze: OpenAIRE
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