An MRI Rating Scale for Amyloid-Related Imaging Abnormalities with Edema or Effusion
| Autor: | Arianne Bechten, Frederik Barkhof, H.R. Brashear, Marita Daams, Kristen Morris, Mike P. Wattjes, H. M. Arrighi, Ph. Scheltens, M. McGovern |
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| Přispěvatelé: | Radiology and nuclear medicine, Neurology, NCA - neurodegeneration, NCA - Brain imaging technology |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
animal structures Intraclass correlation Brain Edema Fluid-attenuated inversion recovery Antibodies Monoclonal Humanized Sensitivity and Specificity Severity of Illness Index Rating scale Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Bapineuzumab Subdural effusion Aged Observer Variation medicine.diagnostic_test business.industry Brain Reproducibility of Results Magnetic resonance imaging medicine.disease Image Enhancement Magnetic Resonance Imaging Hyperintensity Subdural Effusion Cerebral Amyloid Angiopathy Effusion Female Neurology (clinical) Nuclear medicine business Algorithms medicine.drug |
| Zdroj: | AJNR Am J Neuroradiol Barkhof, F, Daams, M, Scheltens, P, Brashear, H R, Arrighi, H M, Bechten, A K, Morris, K, McGovern, M & Wattjes, M P 2013, ' An MRI rating scale for amyloid-related imaging abnormalities with edema or effusion ', American Journal of Neuroradiology, vol. 34, no. 8, pp. 1550-1555 . https://doi.org/10.3174/ajnr.A3475 American Journal of Neuroradiology, 34(8), 1550-1555. American Society of Neuroradiology |
| ISSN: | 0195-6108 |
| DOI: | 10.3174/ajnr.A3475 |
| Popis: | BACKGROUND AND PURPOSE: Immune therapy against amyloid-β appears to be a promising target in Alzheimer disease. However, a dose-related risk for ARIA on FLAIR images thought to represent parenchymal vasogenic edema or sulcal effusion (termed “ARIA-E”), has been observed in clinical trials. To assess the intensity of ARIA-E presentation, an MR imaging scale that is both reproducible and easily implemented would assist in monitoring and evaluating this adverse event. MATERIALS AND METHODS: On the basis of a review of existing cases from a phase II bapineuzumab study, a scale was constructed with a 6-point score for the 6 regions on each side of the brain (range, 0–60). Scores would be obtained for both parenchymal and sulcal hyperintensities and frequently co-occurring gyral swelling. Inter-rater reliability between 2 neuroradiologists was evaluated in 20 patients, 10 with known ARIA-E and 10 without, by using the intraclass correlation coefficient. RESULTS: The 2 raters had excellent agreement in the identification of ARIA-E cases. A high inter-rater agreement was observed for scores of parenchymal hyperintensity (ICC = 0.83; 95% CI, 48–96) and sulcal hyperintensity (ICC = 0.89; 95% CI, 63–97) and for the combined scores of the 2 ARIA-E findings (ICC = 0.89; 95% CI, 62–97). Gyral swelling scores were observed to have lower inter-rater agreement (ICC = 0.54; 95% CI, −0.06–0.86). CONCLUSIONS: The proposed rating scale provides a reliable and easily implemented instrument to grade ARIA-E imaging findings. We currently do not recommend including swelling. |
| Databáze: | OpenAIRE |
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