Self-Assembling Hydrogels Based on a Complementary Host–Guest Peptide Amphiphile Pair
| Autor: | Carlos Redondo-Gómez, C. Remzi Becer, Alvaro Mata, Yamin Abdouni |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nanostructure
Materials science Polymers and Plastics Adamantane Nanofibers Bioengineering Nanotechnology macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Mice chemistry.chemical_compound Materials Testing Self assembling Amphiphile Materials Chemistry Peptide amphiphile Animals chemistry.chemical_classification beta-Cyclodextrins Hydrogels 021001 nanoscience & nanotechnology 0104 chemical sciences Supramolecular polymers chemistry Nanofiber Self-healing hydrogels NIH 3T3 Cells Peptides 0210 nano-technology |
| Zdroj: | Biomacromolecules. 20:2276-2285 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | Supramolecular polymer-based biomaterials play a significant role in current biomedical research. In particular, peptide amphiphiles (PAs) represent a promising material platform for biomedical applications given their modular assembly, tunability, and capacity to render materials with structural and molecular precision. However, the possibility to provide dynamic cues within PA-based materials would increase the capacity to modulate their mechanical and physical properties and, consequently, enhance their functionality and broader use. In this study, we report on the synthesis of a cationic PA pair bearing complementary adamantane and β-cyclodextrin host-guest cues and their capacity to be further incorporated into self-assembled nanostructures. We demonstrate the possibility of these recognition motifs to selectively bind, enabling noncovalent cross-linking between PA nanofibers and endowing the resulting supramolecular hydrogels with enhanced mechanical properties, including stiffness and resistance to degradation, while retaining in vitro biocompatibility. The incorporation of the host-guest PA pairs in the resulting hydrogels allowed not only for macroscopic mechanical control from the molecular scale, but also for the possibility to engineer further spatiotemporal dynamic properties, opening opportunities for broader potential applications of PA-based materials. |
| Databáze: | OpenAIRE |
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