Effect of baclofen on in vitro noradrenaline release from rat hippocampus and cerebellum: an action at an ?(2)-adrenoceptor
| Autor: | Marianne Fillenz, M.J. Swarbrick, S.-C. Fung |
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| Rok vydání: | 1984 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Chemistry organic chemicals musculoskeletal neural and ocular physiology Cell Biology GABAB receptor Bicuculline Yohimbine body regions Cellular and Molecular Neuroscience chemistry.chemical_compound Baclofen Endocrinology nervous system Internal medicine medicine Veratridine Neurotransmitter 5-HT receptor medicine.drug |
| Zdroj: | Neurochemistry international. 7(1) |
| ISSN: | 0197-0186 |
| Popis: | The release of [ 3 H]noradrenaline from rat hippocampal synaptosomes by 25 mM K + and 5 μM veratridine, but not by the Ca 2+ ionophore A23187 was depressed by baclofen. This depression was reversed by 8-Bromo-cAMP. This action of baclofen was stereospecific and mimicked both that of GABA in the presence of bicuculline and that of clonidine. The α 2 -adrenoceptor antagonists yohimbine and Wy25309 antagonised the action of clonidine and baclofen but not that of GABA. Specific binding of [ 3 H]clonidine was displaced by Wy25309 and baclofen, but not by GABA. Specific binding of [ 3 H]GABA in the presence of Ca 2+ was displaced by baclofen but not by Wy25309. It is concluded that baclofen is not a specific agonist at GABA B receptors in the brain. |
| Databáze: | OpenAIRE |
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