Serologic Response of 2 Versus 3 Doses and Intradermal Versus Intramuscular Administration of a Licensed Rabies Vaccine for Preexposure Prophylaxis
| Autor: | Mark Abbott, Mark Polhemus, Richard G. Jarman, Dongliang Wang, Lisa Ware, Paul B. Keiser, Timothy P. Endy, Stephen J. Thomas, Don Cibula, Hengsheng Fang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Injections Intradermal Rabies 030231 tropical medicine Immunization Secondary Antibodies Viral Injections Intramuscular law.invention 03 medical and health sciences Pre-exposure prophylaxis Young Adult 0302 clinical medicine Rabies vaccine Immunogenicity Vaccine Randomized controlled trial law Internal medicine Immunology and Allergy Medicine Humans 030212 general & internal medicine Neutralizing antibody Immunization Schedule biology business.industry Vaccination Antibody titer Middle Aged medicine.disease Antibodies Neutralizing Titer Infectious Diseases Rabies Vaccines Rabies virus biology.protein Linear Models Female Pre-Exposure Prophylaxis business Post-Exposure Prophylaxis medicine.drug |
| Zdroj: | The Journal of infectious diseases. 221(9) |
| ISSN: | 1537-6613 |
| Popis: | Background The World Health Organization recommends intradermal (ID) administration of rabies vaccine for preexposure prophylaxis. Methods In a randomized trial in adults assigned to 1 of 6 treatment groups (ID vs intramuscular [IM], 2 vs 3 doses, and controls), rabies neutralizing antibody titers were measured to 1 year postvaccination. Results ID vaccination produced acceptable antibody levels in all subjects (2- and 3-dose groups). At day 365, acceptable levels were 40% for IM and 50% for ID 2-dose schedule, and 70% for IM and 60% for ID 3-dose schedule. Conclusions ID rabies vaccination induces acceptable antibody titers at a fraction of the dose. Clinical Trials Registration NCT02374814. |
| Databáze: | OpenAIRE |
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