Evaluation of mAST/tAST ratio as a marker of alcohol misuse in a non-selected population
| Autor: | Bernard Lacour, Renée E. Poupon, Anne Vassault, Sage Y, Hauzanneau P, Bertrand Nalpas, François Schellenberg, Pierre Berthelot |
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| Předmět: |
Adult
Male medicine.medical_specialty Population Alcohol chemistry.chemical_compound Internal medicine Medicine Humans Aspartate Aminotransferases education Aged education.field_of_study business.industry Nutritional status General Medicine Clinical Enzyme Tests Middle Aged Surgery Mitochondria Alcoholism chemistry Female business Alcohol consumption Mitochondrial Aspartate Aminotransferase |
| Zdroj: | Europe PubMed Central |
| Popis: | Serum mitochondrial aspartate aminotransferase (mAST) and gamma-glutamyl transpeptidase activities were measured in 303 outpatients upon visits to their general practitioner. Alcohol consumption was evaluated by interview, using a standard questionnaire. Thirty-four patients drank more than 80 g of alcohol per day but none complained of an alcohol-related disease. These 34 heavy drinkers presented a mean serum mAST value which was significantly higher than that of the 269 normal drinkers; however, only 14 Out of the 34 (41%) exhibited an increased mAST value. The sensitivity, specificity and predictive positive value of the mASTI/tAST ratio were 0.29, 0.77 and 0.13, respectively; the corresponding figures for GGT were 0.5, 0.81 and 0.23, respectively. These results are in sharp contrast with those obtained for mAST activity in a population of hospitalized alcoholics. The explanation may lie in differences in alcohol consumption, in nutritional status and in the frequency of alcohol-related diseases in inpatients as compared to outpatients. |
| Databáze: | OpenAIRE |
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