Do Beliefs about the Pathogenetic Role of Amyloid Affect the Interpretation of Amyloid PET in the Clinic
| Autor: | Boccardi M., Altomare D., Ferrari C., Festari C., Antelmi L., Pievani M., Tarallo A., Muscio C., Guerra U. P., Paghera B., Padovani A., Frisoni G. B., Zanetti O., Anzola G. P., Bertocchi M., Chito E., Galluzzi S., Geroldi C., Lussignoli G., Mattioli F., Moretti D., Pizzocaro C., Borroni B., Rozzini L., Prelle A., Gennuso M., Villani D., Raimondi M. C., Gentile S., Bellelli G., Morandi A., Turco R., Bellandi D., Carbone P., Abruzzi L., Bettoni L., Bianchetti A., Facchi E., Di Fazio I., Turla M., Cotelli M. S., Volta G. D., Bigni B., Bilotti G., Vollaro S., Rozzini R., Boffelli S., Cappuccio M., Conti M. Z., Guizzetti G., Defanti C., Mirabile D., Fascendini S., Manzoni L., Salvi G. P., Belotti G., Cavaliere S., Fiacco F., Valente L., Ciccone A., Lanari A., Selletti L., Palmerini F., Avanzi S., Vezzadini G. |
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| Přispěvatelé: | Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Antelmi, L, Pievani, M, Tarallo, A, Muscio, C, Guerra, U, Paghera, B, Padovani, A, Frisoni, G, Zanetti, O, Anzola, G, Bertocchi, M, Chito, E, Galluzzi, S, Geroldi, C, Lussignoli, G, Mattioli, F, Moretti, D, Pizzocaro, C, Borroni, B, Rozzini, L, Prelle, A, Gennuso, M, Villani, D, Raimondi, M, Gentile, S, Bellelli, G, Morandi, A, Turco, R, Bellandi, D, Carbone, P, Abruzzi, L, Bettoni, L, Bianchetti, A, Facchi, E, Di Fazio, I, Turla, M, Cotelli, M, Volta, G, Bigni, B, Bilotti, G, Vollaro, S, Rozzini, R, Boffelli, S, Cappuccio, M, Conti, M, Guizzetti, G, Defanti, C, Mirabile, D, Fascendini, S, Manzoni, L, Salvi, G, Belotti, G, Cavaliere, S, Fiacco, F, Valente, L, Ciccone, A, Lanari, A, Selletti, L, Palmerini, F, Avanzi, S, Vezzadini, G |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Amyloid Attitude of Health Personnel Tau Proteins/metabolism Amyloid pet tau Proteins Pilot Projects Disease Affect (psychology) Amyloid/metabolism Diagnosis Differential 03 medical and health sciences ddc:616.89 Alzheimer's disease pathogenesis Amyloid positron emission tomography Differential diagnosis Incremental diagnostic value 0302 clinical medicine Neuroimaging Positron-Emission Tomography/psychology Alzheimer Disease Physicians Physicians/psychology mental disorders Diagnosis Medicine Dementia Humans business.industry Alzheimer Disease/diagnosis/diagnostic imaging/metabolism medicine.disease eye diseases 030104 developmental biology Neurology Italy Positron-Emission Tomography Differential sense organs Neurology (clinical) Alzheimer's disease business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurodegenerative Diseases, Vol. 16, No 1-2 (2016) pp. 111-7 |
| ISSN: | 1660-2854 |
| Popis: | Background: Beliefs of dementia experts about the pathogenic role of amyloid in Alzheimer's disease (AD) may affect the use of amyloid positron emission tomography (PET). Objective: To assess the role attributed to amyloid in AD pathogenesis by Italian dementia experts, and whether this modulates the impact of amyloid PET results in their diagnostic workup. Methods: 22 dementia experts rated their beliefs about the pathogenic role of amyloid. Then, we asked them to rate the probability of change in diagnosis based on the result of amyloid PET for 7 case vignettes, depicting patients who initially received a diagnosis based on a comprehensive workup and later received amyloid PET results consistent or inconsistent with the clinical picture. Results: 55% of the experts assigned a dominant role to amyloid, and 32% attributed a similar role to amyloid and tau in AD pathogenesis. The probability of change in diagnosis ranged from 17% (SD = 21.6) for cases with consistent to 51% (SD = 34) for cases with inconsistent PET versus clinical data. Diagnostic change was not biased by the clinicians' beliefs about AD pathogenesis. Conclusions: This work supports an unbiased interpretation of amyloid PET across different beliefs about the pathogenic role of amyloid, and a belief-independent reluctance to change diagnosis in cases where change is expected and recommended. |
| Databáze: | OpenAIRE |
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