The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model

Autor: E. Vivoli, Nicoletta Galeotti, Irene Grazioli, Carla Ghelardini, Carla Uslenghi
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Drug
Male
Original
media_common.quotation_subject
Migraine Disorders
Analgesic
Indomethacin
Clinical Neurology
Drug Evaluation
Preclinical
Pharmacology
GTP-Binding Protein alpha Subunits
Gi-Go
Prochlorperazine
chemistry.chemical_compound
Mice
Gi proteins
Indometacin
In vivo
Caffeine
medicine
Animals
Migraine
media_common
Analgesics
business.industry
Sumatriptan
Anti-Inflammatory Agents
Non-Steroidal
Brain
Drug Synergism
General Medicine
Anti-Inflammatory Agents
Non-Steroidal
Central Nervous System Stimulants
Cerebral Arteries
Disease Models
Animal
Dopamine Antagonists
Drug Combinations
Drug Evaluation
Preclinical
GTP-Binding Protein alpha Subunits
Gi-Go
Serotonin Agonists
Treatment Outcome
medicine.disease
Serotonin Receptor Agonists
Disease Models
Animal
Anesthesiology and Pain Medicine
chemistry
Anesthesia
Neurology (clinical)
business
medicine.drug
Zdroj: The Journal of Headache and Pain
ISSN: 1129-2377
1129-2369
Popis: A hypofunctionality of Gi proteins has been found in migraine patients. The fixed combination of indomethacin, prochlorperazine and caffeine (Indoprocaf) is a drug of well-established use in the acute treatment of migraine and tension-type headache. The aim of this study was to investigate if Indoprocaf was able to exert its central antinociceptive action when Gi proteins activity is abolished by pertussis toxin (PTX), compared to its single active ingredients and to sumatriptan. The mice model of abdominal constriction test induced by an i.p. injection of a 0.6% solution of acetic acid was used. The study showed that Indoprocaf (a fixed combination of indomethacin 1 mg/kg, prochlorperazine 1 mg/kg and caffeine 3 mg/kg, s.c.) and sumatriptan (20 mg/kg, s.c.) exert their central antinociceptive action independently from the Gi proteins. In addition, the antinociceptive efficacy of Indoprocaf in this study was statistically superior to that of sumatriptan. This study also showed that the single active ingredients of Indoprocaf, indomethacin (1 mg/kg, s.c.), prochlorperazine (1 mg/kg, s.c.) and caffeine (3 mg/kg, s.c.), were able to exert their central antinociceptive action independently from the Gi proteins. However, Indoprocaf at analgesic doses was able to abolish almost completely the abdominal constrictions, with a statistically higher efficacy compared to the single active ingredients, showing an important synergic effect of Indoprocaf. This synergic effect was evident not only when Gi proteins activity was abolished by PTX, but also under control condition, when Gi proteins were active. This study suggests that the central antinociceptive action induced by antimigraine drugs is independent from Gi proteins.
Databáze: OpenAIRE
Externí odkaz: