Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage

Autor: Stuart G. Clarkson, Mahmud K.K. Shivji, Thierry Nouspikel, Angelos Constantinou, Wim Vermeulen, Philippe Lalle, Fabrizio Thorel, Richard D. Wood, Anja Raams, Nicolaas G. J. Jaspers, Isabelle Dunand-Sauthier
Přispěvatelé: Molecular Genetics, Deleage, Gilbert
Rok vydání: 2004
Předmět:
Male
Xeroderma pigmentosum
DNA Repair
Ultraviolet Rays
DNA repair
DNA damage
DNA Mutational Analysis
Immunoblotting
Longevity
Cockayne syndrome
Cell Line
Transcription Factors
TFII

Endonuclease
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology

medicine
Humans
Amino Acid Sequence
Fluorescent Antibody Technique
Indirect

Frameshift Mutation
Molecular Biology
Cell Line
Transformed

Genetics
Xeroderma Pigmentosum
biology
Lentivirus
Nuclear Proteins
Cell Biology
Fibroblasts
Cell Transformation
Viral

Endonucleases
medicine.disease
DNA Dynamics and Chromosome Structure
Precipitin Tests
Recombinant Proteins
Protein Structure
Tertiary

DNA-Binding Proteins
Alternative Splicing
Transcription Factor TFIIH
Microscopy
Fluorescence

Transcription factor II H
biology.protein
DNA Damage
Transcription Factors
Nucleotide excision repair
Zdroj: Molecular and Cellular Biology, 24(24), 10670-10680. American Society for Microbiology
ISSN: 0270-7306
DOI: 10.1128/mcb.24.24.10670-10680.2004
Popis: XPG is the human endonuclease that cuts 3' to DNA lesions during nucleotide excision repair. Missense mutations in XPG can lead to xeroderma pigmentosum (XP), whereas truncated or unstable XPG proteins cause Cockayne syndrome (CS), normally yielding life spans of
Databáze: OpenAIRE