Discovery and functional evaluation of diverse novel human CB1 receptor ligands

Autor:	Nathaniel J. T. Monck, A Misra, K Benwell, Teresa Brooks, Antony R. Knight, Nicolas Foloppe, Guy A. Kennett
Rok vydání:	2009
Předmět:	Cannabinoid receptor Molecular model Chemistry Pharmaceutical medicine.medical_treatment Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Ligands Biochemistry Receptor Cannabinoid CB2 Mice Piperidines Receptor Cannabinoid CB1 Rimonabant Drug Discovery medicine Animals Humans Obesity Receptor Molecular Biology Binding selectivity Cannabis Virtual screening Dose-Response Relationship Drug Molecular Structure Cannabinoids Chemistry Organic Chemistry Models Chemical Drug Design Pyrazoles Molecular Medicine Cannabinoid Pharmacophore medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:4183-4190
ISSN:	0960-894X
Popis:	Ligand-based virtual screening with a 3D pharmacophore led to the discovery of 30 novel, diverse and drug-like ligands of the human cannabinoid receptor 1 (hCB(1)). The pharmacophore was validated with a hit rate of 16%, binding selectivity versus hCB(2), and expected functional profiles. The discovered compounds provide new tools for exploring cannabinoid pharmacology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78742d20c950f66388c9a544e566cbed https://doi.org/10.1016/j.bmcl.2009.05.114 Zobrazit plný text záznamu Full Text from ScienceDirect