Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma

Autor:	Guoshu Bi, Valeria Besskaya, Huan Zhang, Jiaqi Liang, Guangyao Shan, Songtao Xu, Zhencong Chen, Lin Wang, Yuansheng Zheng, Cheng Zhan, Weigang Guo, Benjie Cai
Rok vydání:	2021
Předmět:	Adult Male ALK inhibitors Pulmonary and Respiratory Medicine Oncology medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Adenocarcinoma of Lung Pulmonary Surgical Procedures Targeted therapy hemic and lymphatic diseases Internal medicine medicine Humans Anaplastic Lymphoma Kinase Radical surgery Stage (cooking) Pathological RC254-282 Aged Retrospective Studies Gene Rearrangement Univariate analysis business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Retrospective cohort study Original Articles General Medicine Middle Aged lung adenocarcinoma medicine.disease Primary tumor clinical feature Survival Rate anaplastic lymphoma kinase (ALK) Case-Control Studies Adenocarcinoma Female Original Article prognosis business
Zdroj:	Thoracic Cancer, Vol 12, Iss 22, Pp 3011-3018 (2021) Thoracic Cancer
ISSN:	1759-7714 1759-7706
Popis:	Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. Methods This was a retrospective cohort study of 80 ALK‐rearranged lung adenocarcinoma patients who had undergone radical surgery and another 3031 ALK mutation‐negative patients were retrospectively reviewed for inclusion in this case‐controlled analyses. Overall survival (OS) was evaluated using the Kaplan‐–Meier method. Univariate analysis (UVA) and multivariate analysis (MVA) by the Cox proportional hazards regression identified risk factors that predicted OS. Results Compared to ALK‐negative patients, the ALK rearranged patients were younger, with more non‐smokers, more females, a larger primary tumor was demonstrated, and were a higher pathological stage. In particular, the risk of lymph node metastasis was higher. For patients with surgically‐resected tumors, the prognosis was better for ALK rearranged patients (HR = 0.503; 95% CI: 0.259–0.974, p = 0.041). In addition, for stage II–III patients, targeted therapy was an independent prognostic factor of better OS (HR = 0.159; 95% CI: 0.032–0.801, p = 0.026). Conclusions ALK rearranged lung adenocarcinoma patients who have undergone radical surgery have distinct clinical features. Patients with ALK rearrangement may have a favorable prognosis, and stage II–III patients may benefit from targeted treatment. The article compared 80 ALK+ and 3031 ALK‐ lung adenocarcinoma patients after surgery, explored the clinicopathological characteristics and prognostic features of ALK+ lung adenocarcinoma patients, and analyzed the impact of targeted drugs on the survival of ALK+ lung adenocarcinoma patients after surgery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78722f929edd2f16157d56c3e4829be9 https://doi.org/10.1111/1759-7714.14170 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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