Anorectal carcinoma after infliximab therapy in Crohn's disease: report of a case
| Autor: | Jan Bures, Bohuslav Melichar, Karel Dedic |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adenocarcinoma Gastroenterology Crohn Disease Surgical oncology Internal medicine medicine Carcinoma Humans Crohn's disease Abdominoperineal resection business.industry Rectal Neoplasms Cancer Antibodies Monoclonal Combination chemotherapy General Medicine medicine.disease Infliximab Surgery Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Diseases of the colon and rectum. 49(8) |
| ISSN: | 0012-3706 |
| Popis: | Infliximab, monoclonal antibody against tumor necrosis factor alpha, is an effective agent in the therapy of Crohn's disease. Although therapy with infliximab is generally well tolerated, there is an obvious concern about the effect of this treatment on the incidence of cancer. We report a case of mucinous anorectal adenocarcinoma observed in a 39-year-old patient with long-standing Crohn's disease after therapy with two courses of infliximab. The carcinoma was discovered fortuitously after abdominoperineal resection. Despite clear margins, the tumor recurred in a few months and progressed during combination chemotherapy. Although there is currently no definitive proof of a causal link between infliximab therapy and cancer, the present observation and other reports in the literature should lead to a careful evaluation of the possibility of increased cancer risk in patients treated with this new agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink