Secondary non-invasive prenatal screening for fetal trisomy: an effectiveness study in a public health setting
| Autor: | G. P. Guy, Safe test collaborative, J Short, K Price, R Dunn, B. Thilaganathan, J Hargrave |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors National Health Programs Noninvasive Prenatal Testing Gestational Age Trisomy Logistic regression Malignancy 03 medical and health sciences 0302 clinical medicine Pregnancy Medicine Humans Twin Pregnancy Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics Public health Obstetrics and Gynecology Gestational age Retrospective cohort study medicine.disease United Kingdom Fetal Diseases Logistic Models Cell-free fetal DNA Feasibility Studies Female business Program Evaluation |
| Zdroj: | BJOG : an international journal of obstetrics and gynaecologyReferences. 128(2) |
| ISSN: | 1471-0528 |
| Popis: | OBJECTIVE To evaluate the effectiveness of secondary screening using non-invasive prenatal testing (NIPT) in a routine NHS setting including test performance, turn-around times (TATs) and no-call (failure to obtain result) rates. To examine the influence of maternal and fetal characteristics on test performance. DESIGN Retrospective cohort. SETTING London teaching hospital. SAMPLE A total of 8651 pregnancies undergoing screening for fetal trisomy using NIPT provided by an NHS cell-free DNA screening laboratory - the SAFE laboratory. METHODS Screening test evaluation and TATs. Univariate and multivariate logistic regression analysis to identify significant predictors of no-call results and reported by low fetal fraction ( 40%) and processing failure. MAIN OUTCOME MEASURES Test performance, TATs and no-call rates, factors affecting no-call results. RESULTS Average TAT was 4.0 days (95% CI 4.0-4.2 days). Test sensitivities for trisomies 21 and 13/18 were 98.9% (95% CI 95.9-99.9%) and 90.4% (95% CI 80.0-96.8%), respectively. The overall no-call rate was 32/8651 (0.37%, 95% CI 0.26-0.52%). The overall risk of a no-call result was influenced by gestational age, dichorionic twin pregnancy, history of malignancy and pregnancies affected by trisomy 13/18, but not by maternal weight or use of low-molecular-weight heparin. CONCLUSIONS High-throughput NIPT can be effectively embedded into a public health NHS setting. TATs of 4 days and no-calls of |
| Databáze: | OpenAIRE |
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