Regulation of Rho GTPases by RhoGDIs in Human Cancers
| Autor: | Kyoung Eun Baek, Hee Jun Cho, Jong-Tae Kim, Hee Gu Lee, Bo Yeon Kim |
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| Rok vydání: | 2019 |
| Předmět: |
rho GTP-Binding Proteins
Guanine Nucleotide Dissociation Inhibitors SUMO protein Rho GTPases Cell migration Review General Medicine GTPase Biology migration Cell biology RhoGDI2 lcsh:Biology (General) RhoGDI1 Neoplasms Humans rho-Specific Guanine Nucleotide Dissociation Inhibitors cancer metastasis Phosphorylation lcsh:QH301-705.5 Protein Processing Post-Translational Protein Binding Malignant phenotype |
| Zdroj: | Cells Cells, Vol 8, Iss 9, p 1037 (2019) |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells8091037 |
| Popis: | Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family. Dissociation of Rho GTPases from RhoGDIs is necessary for their spatiotemporal activation and is dynamically regulated by several mechanisms, such as phosphorylation, sumoylation, and protein interaction. The expression of RhoGDIs has changed in many human cancers and become associated with the malignant phenotype, including migration, invasion, metastasis, and resistance to anticancer agents. Here, we review how RhoGDIs control the function of Rho GTPases by regulating their spatiotemporal activity and describe the regulatory mechanisms of the dissociation of Rho GTPases from RhoGDIs. We also discuss the role of RhoGDIs in cancer progression and their potential uses for therapeutic intervention. |
| Databáze: | OpenAIRE |
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