Simultaneous multiparametric PET/MRI for the assessment of therapeutic response to chemotherapy or concurrent chemoradiotherapy of cervical cancer patients: Preliminary results
| Autor: | Axel Wetter, Alexander Tschischka, Lale Umutlu, Vanessa Stebner, Michael Forsting, Ken Herrmann, Rainer Kimmig, Theresia Sarabhai, Felix Nensa, Johannes Grueneisen |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Medizin Uterine Cervical Neoplasms Cervix Uteri 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Outcome Assessment Health Care medicine Humans Radiology Nuclear Medicine and imaging Aged Cervical cancer Chemotherapy medicine.diagnostic_test Tumor size Multiparametric Analysis business.industry Magnetic resonance imaging Chemoradiotherapy Middle Aged medicine.disease Magnetic Resonance Imaging Concurrent chemoradiotherapy Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | Clinical Imaging. 49:163-168 |
| ISSN: | 0899-7071 |
| Popis: | Purpose To assess the response to initial treatment strategies of cervical cancer using multiparametric-PET/MRI. Material and methods PET/MR-derived morphological (tumor size), functional (DWI, DCE-MRI) and metabolic (18F-FDG PET) parameters were acquired in pre- and posttreatment examinations of 8 patients. Besides RECIST- and PERCIST-criteria, functional quantitative parameters were used to assess therapeutic response. Results RECIST- and PERCIST-response criteria demonstrated high correlations for the differentiation between therapy-responders and non-responders, which was additionally reflected by functional (DWI, DCE-MRI) quantitative imaging parameters. Conclusion Multiparametric-PET/MRI bears the potential of a more comprehensive response assessment of initial treatment strategies in cervical cancer patients. |
| Databáze: | OpenAIRE |
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