Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism

Autor: Hala Fatrouni, Véronique Trézéguet, Aksam Merched
Přispěvatelé: Merched, Aksam, Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
QH301-705.5
kynurenin
Carcinogenesis
[SDV]Life Sciences [q-bio]
TDO2
[SDV.CAN]Life Sciences [q-bio]/Cancer
Review
liver cancer
IDO1
[SDV.CAN] Life Sciences [q-bio]/Cancer
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
Immune Tolerance
Tumor Microenvironment
Humans
Indoleamine-Pyrrole 2
3
-Dioxygenase
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Biology (General)
immuno-oncology
Kynurenine
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Liver Neoplasms
Tryptophan
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
General Medicine
hepatoblastoma
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Tryptophan Oxygenase
[SDV] Life Sciences [q-bio]
Liver
metabolism
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Cells
Cells, Vol 10, Iss 3469, p 3469 (2021)
Cells, 2021, 10 (12), pp.3469. ⟨10.3390/cells10123469⟩
ISSN: 2073-4409
DOI: 10.3390/cells10123469⟩
Popis: International audience; Metabolic rewiring in tumor cells is a major hallmark of oncogenesis. Some of the oncometabolites drive suppressive and tolerogenic signals from the immune system, which becomes complicit to the advent and the survival of neoplasia. Tryptophan (TRP) catabolism through the kynurenine (KYN) pathway was reported to play immunosuppressive actions across many types of cancer. Extensive debate of whether the culprit of immunosuppression was the depletion of TRP or rather KYN accumulation in the tumor microenvironment has been ongoing for years. Results from clinical trials assessing the benefit of inhibiting key limiting enzymes of this pathway such as indoleamine 2,3-dioxygenase (IDO1) or tryptophan 2,3-dioxygenase (TDO2) failed to meet the expectations. Bearing in mind the complexity of the tumoral terrain and the existence of different cancers with IDO1/TDO2 expressing and non-expressing tumoral cells, here we present a comprehensive analysis of the TRP global metabolic hub and the driving potential of the process of oncogenesis with the main focus on liver cancers.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje