White matter integrity differences associated with post-traumatic stress disorder are not normalized by concurrent marijuana use
Autor: | Alyson Dechert, Kevin Potter, Hannah C. Broos, Nina Levar, Jodi M. Gilman, Chien-Lin Yeh, A. Eden Evins |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Neuroscience (miscellaneous) Comorbidity Audiology behavioral disciplines and activities Article Stress Disorders Post-Traumatic White matter Young Adult 03 medical and health sciences 0302 clinical medicine Marijuana use Brain White Matter mental disorders Fractional anisotropy Humans Cingulum (brain) Medicine Radiology Nuclear Medicine and imaging In patient business.industry Traumatic stress Brain Middle Aged White Matter 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Diffusion Tensor Imaging medicine.anatomical_structure Anisotropy Marijuana Use Nerve Net business 030217 neurology & neurosurgery Diffusion MRI |
Zdroj: | Psychiatry Res Neuroimaging |
ISSN: | 0925-4927 |
Popis: | Marijuana (MJ) use and post-traumatic stress disorder (PTSD) have both been associated with abnormalities in brain white matter tracts, including the cingulum and the anterior thalamic radiations (ATR), which project from subcortical regions to frontal cortex. Studies have not assessed the integrity of these tracts in patients with comorbid PTSD and MJ use. To examine effects of PTSD and MJ use on brain structure, we performed diffusion tensor imaging scans on seventy-two trauma-exposed participants, categorized into four groups: those with PTSD who used MJ at least weekly (PTSD+MJ; n = 20), those with PTSD with no regular MJ use (PTSD; n = 19), trauma-exposed controls without PTSD who used MJ (TEC+MJ; n = 14) and trauma-exposed controls with no PTSD or MJ use (TEC; n = 19). White matter integrity was evaluated by calculating fractional anisotropy (FA). Results showed that while FA values in the right ATR and the cingulum differed across groups, there were no significant interactions between PTSD and MJ in any white matter tracts, indicating that MJ exposure neither normalizes nor worsens white matter abnormalities in those with PTSD. Further study is needed to evaluate the impact of MJ use on other neurobiological markers of PTSD. |
Databáze: | OpenAIRE |
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