Clindamycin therapy for Chlamydia trachomatis in women
| Autor: | William F. Campbell, Melvin G. Dodson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Side effect Adolescent medicine.drug_class Antibiotics Population Erythromycin Chlamydia trachomatis medicine.disease_cause Asymptomatic Double-Blind Method Internal medicine Medicine Humans Chlamydiaceae Prospective Studies education Child Randomized Controlled Trials as Topic education.field_of_study biology business.industry Incidence (epidemiology) Clindamycin Incidence Age Factors Obstetrics and Gynecology General Medicine Middle Aged biology.organism_classification Surgery Uterine Cervicitis Lymphogranuloma Venereum Neisseria gonorrhoeae Drug Therapy Combination Female medicine.symptom business medicine.drug |
| Zdroj: | American journal of obstetrics and gynecology. 162(2) |
| ISSN: | 0002-9378 |
| Popis: | The population for this study consisted of 4013 sexually active women seen for family planning. Culture for Chlamydia trachomatis yielded an isolation rate of 6.1%. Women aged 16 to 25 accounted for 81.7% of the C. trachomatis infections, while those younger than 16 or older than 35 accounted for only 2.4% of the infections. Of the 246 patients whose cultures were positive for C. trachomatis , 159 (65%) were asymptomatic. The incidence of C. trachomatis was 11.2% among those with symptoms but only 6.4% among the asymptomatic group. Among 63 patients with Neisseria gonorrhoeae (who were excluded from the study), 26 (41.3%) also were infected by C. trachomatis . There were no microbiologic drug failures with erythromycin or clindamycin. Of 56 patients who enrolled in the clindamycin arm of the protocol, 48 (85.7%) completed therapy and experienced microbiologic and clinical cures. In contrast, erythromycin therapy was completed by only 25 of 57 women (43.9%) enrolled. The number of side effect failures for erythromycin was 22 of 57 (38.6%). This was more than five times the number of side effect failures for clindamycin (4 of 56, or 7.1%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|