Resveratrol and exercise to treat functional limitations in late life: Design of a randomized controlled trial
| Autor: | Bhanuprasad Sandesara, Samuel S. Wu, Robert T. Mankowski, Stephen D. Anton, Thomas W. Buford, Andrew S. Layne, Marco Pahor, Christiaan Leeuwenburgh, Lisa M. Krehbiel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Short Physical Performance Battery Resveratrol Physical function Placebo Article law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physical medicine and rehabilitation Randomized controlled trial law Aerobic exercise Medicine Pharmacology lcsh:R5-920 business.industry Resistance training Skeletal muscle General Medicine Resistance exercise 3. Good health Mitochondria 030104 developmental biology medicine.anatomical_structure chemistry Physical therapy business lcsh:Medicine (General) 030217 neurology & neurosurgery |
| Zdroj: | Contemporary Clinical Trials Communications, Vol 6, Iss C, Pp 58-63 (2017) Contemporary Clinical Trials Communications |
| ISSN: | 2451-8654 |
| Popis: | Skeletal muscle mitochondrial function declines with age and is a key factor in the maintenance of physical function among older adults. Research studies from animals and humans have consistently demonstrated that exercise improves skeletal muscle mitochondrial function in early and middle adulthood. However, mitochondrial adaptations to both acute and chronic exercise are attenuated in late life. Thus, there is an important need to identify adjuvant therapies capable of augmenting mitochondrial adaptations to exercise (e.g. improved mitochondrial respiration, muscle mitochondria biogenesis) among older adults. This study is investigating the potential of resveratrol supplementation for this purpose. The objective of this randomized, double-masked pilot trial is to evaluate the efficacy of resveratrol supplementation combined with a comprehensive supervised exercise program exercise for improving physical function among older adults. Moderately functioning, sedentary participants aged ≥60 years will perform 24 sessions (2 day/wk for 12 weeks) of center-based walking and resistance training and are randomly assigned to receive either (1) 500 mg/day resveratrol (2) 1000 mg/day resveratrol or (3) placebo. Study dependent outcomes include changes in 1) knee extensor strength, 2) objective measures of physical function (e.g. 4 m walk test, Short Physical Performance Battery), 3) subjective measures of physical function assessed by Late Life Function and Disability Instrument, and 4) skeletal muscle mitochondrial function. This study will provide novel information regarding the therapeutic potential of resveratrol supplementation combined with exercise while also informing about the long-term clinical viability of the intervention by evaluating participant safety and willingness to engage in the intervention. |
| Databáze: | OpenAIRE |
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