Biocompatibility in vitro tests of Zinalco
| Autor: | Cristina Piña, Leonor Rodríguez, Saúl Espinosa, Ma. de los Ángeles Aguilar |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Mitotic index Biocompatibility Chemistry Health Toxicology and Mutagenesis Biomaterial Biocompatible Materials Pharmacology Middle Aged In vitro Comet assay Clastogen Toxicity Materials Testing Genetics Alloys Mitotic Index Humans Female Implant Comet Assay Lymphocytes Cells Cultured DNA Damage |
| Zdroj: | Mutation research. 446(1) |
| ISSN: | 0027-5107 |
| Popis: | In this study, cultures of human lymphocytes were exposed for 48 h to aqueous suspensions of Zinalco™, with different times of corrosion, to test the biocompatibility of this alloy and support its use in medical implants. The results show that the Zinalco™ concentrations assessed affect the mitotic index (MI) and some also increase the length of DNA migration measured in the comet assay in a significant manner; none of them showed clastogenic nor aneugenic effects. The authors conclude that Zinalco™ may be considered as an alternative biomaterial and suggest its use for short-term implants. |
| Databáze: | OpenAIRE |
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