Author Correction: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
| Autor: | Cuiling Xu, Reem A. Dawoud, Jeffrey M. Weiss, Fredrik Barrenäs, Qingsheng Li, Jan Komorowski, Steven E. Bosinger, Cristian Apetrei, Andrew Nishida, Guido Silvestri, Dongzhu Ma, George H. Richter, Jean Chang, Wuxun Lu, Elise Smith, Michael Gale, Lynn Law, Matthew J. Thomas, Xinxia Peng, Ivona Pandrea, Richard Green, Jianshui Zhang, Kevin D. Raehtz, Anita M. Trichel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Science
Simian Acquired Immunodeficiency Syndrome General Physics and Astronomy General Biochemistry Genetics and Molecular Biology Functional clustering Pathogenesis Transforming Growth Factor beta Chlorocebus aethiops Animals Macrophage Medicine Intestinal Mucosa Author Correction lcsh:Science Wound Healing Multidisciplinary business.industry Macrophages Systems Biology Rectum General Chemistry Macaca mulatta Fibronectins Viral infection Immunology Disease Progression Data integration Simian Immunodeficiency Virus lcsh:Q African Green Monkey Transcriptome business Wound healing |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a natural SIV host, African green monkey (AGM) to an AIDS susceptible species, rhesus macaque (RM). To asses gene expression profiles from acutely SIV infected AGMs and RMs, we developed a systems biology approach termed Conserved Gene Signature Analysis (CGSA), which compared RNA sequencing data from rectal AGM and RM tissues to various other species. We found that AGMs rapidly activate, and then maintain, evolutionarily conserved regenerative wound healing mechanisms in mucosal tissue. The wound healing protein fibronectin shows distinct tissue distribution and abundance kinetics in AGMs. Furthermore, AGM monocytes exhibit an embryonic development and repair/regeneration signature featuring TGF-β and concomitant reduced expression of inflammatory genes compared to RMs. This regenerative wound healing process likely preserves mucosal integrity and prevents inflammatory insults that underlie immune exhaustion in RMs. |
| Databáze: | OpenAIRE |
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