BRAF V600Q-mutated lung adenocarcinoma with duodenal metastasis and extreme leukocytosis
| Autor: | Omar Abughanimeh, Mouhanna Abu Ghanimeh, Sakher Albadarin, Addison Tolentino, Ayman Qasrawi |
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| Rok vydání: | 2017 |
| Předmět: |
Lung adenocarcinoma
Oncology medicine.medical_specialty Pathology Duodenum Leukocytosis Case Report BRAF Metastasis 03 medical and health sciences 0302 clinical medicine Melena Internal medicine Biopsy Medicine Lung cancer Gastrointestinal bleeding Lung medicine.diagnostic_test business.industry Esophagogastroduodenoscopy Endoscopy medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Adenocarcinoma 030211 gastroenterology & hepatology medicine.symptom business Leukemoid reaction |
| Zdroj: | World Journal of Clinical Oncology |
| ISSN: | 2218-4333 |
| Popis: | Driver mutations in patients with non-small cell lung cancer (NSCLC) can lead to distinct behaviors and patterns of metastasis. Mutations in the proto-oncogene B-raf (BRAF) occur in approximately 3% of NSCLC cases. In the literature, reports of patients with lung adenocarcinomas metastasizing to the duodenum are rare, and most of the only 21 cases reported were from before the advent of next-generation sequencing. We present here a case involving a 57-year-old female who had a lytic lesion in her lesser trochanter. Biopsy showed metastatic adenocarcinoma of lung origin. Chest X-ray showed a large left upper lobe mass. Next-generation sequencing analysis confirmed the presence of BRAF V600Q mutation. The patient presented with persistent anemia and melena. Esophagogastroduodenoscopy confirmed the presence of duodenal metastasis. She also had suspected paraneoplastic leukemoid reaction. To our knowledge, this is only the second well-documented case of gastrointestinal metastasis from BRAF-mutated lung cancer. |
| Databáze: | OpenAIRE |
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