Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)
| Autor: | Cristiane da Silva Paula, Kleyton Cardoso de Andrade, Maria Christina Dos Santos Verdam, Karina Lorena Meira Fernandes, Vinícius Bednarczuk de Oliveira, Hector H. F. Koolen, Mayane P. Souza, Patrícia Maria Stuelp-Campelo, Marilis Dallarmi Miguel, Milena Kalegari, Felipe M. A. da Silva, Beatriz Cristina Konopatzki Hirota, Tallita Marques Machado, Cristina Mayumi Sasaki Miyazaki, Obdulio Gomes Miguel, Fernanda Guilhon-Simplicio |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Leukocyte migration Article Subject DPPH lcsh:Medicine Ethyl gallate lcsh:Technology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine TBARS Gallic acid lcsh:Science General Environmental Science biology Traditional medicine lcsh:T lcsh:R Catechin General Medicine biology.organism_classification 030104 developmental biology chemistry Biochemistry Polyphenol Byrsonima lcsh:Q 030217 neurology & neurosurgery |
| Zdroj: | The Scientific World Journal, Vol 2017 (2017) |
| ISSN: | 1537-744X 2356-6140 |
| Popis: | Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text