Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans
Autor: | Carey E. Gleason, Laura M. Hancock, Derek Norton, Mary F. Wyman, Megan Zuelsdorff, Lindsay R. Clark, Sanjay Asthana, Sterling C. Johnson, Heather M. Johnson, Susan Flowers-Benton, Cynthia M. Carlsson |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Apolipoprotein E medicine.medical_specialty Disease Article White People 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Dementia Risk factor Cerebral perfusion pressure Aged Framingham Risk Score business.industry General Neuroscience Brain General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Obesity Black or African American Psychiatry and Mental health Clinical Psychology 030104 developmental biology Blood pressure Heart Disease Risk Factors Cerebrovascular Circulation Cardiology Female Spin Labels Geriatrics and Gerontology business 030217 neurology & neurosurgery |
Zdroj: | J Alzheimers Dis |
ISSN: | 1875-8908 1387-2877 |
Popis: | Background Midlife cardiovascular risk factors increase risk for Alzheimer's disease (AD). Despite disproportionately high cardiovascular disease and dementia rates, African Americans are under-represented in studies of AD risk and research-based guidance on targeting vascular risk factors is lacking. Objective This study investigated relationships between specific cardiovascular risk factors and cerebral perfusion in White and African American adults enriched for AD risk. Methods Participants included 397 cognitively unimpaired White (n = 330) and African American (n = 67) adults enrolled in the Wisconsin Alzheimer's Disease Research Center who underwent pseudo-continuous arterial spin labeling MRI. Multiple linear regression models examined independent relationships between cardiovascular risk factors and mean cerebral perfusion. Subsequent interaction and stratified models assessed the role for APOE genotype and race. Results When risk factor p-values were FDR-adjusted, diastolic blood pressure was significantly associated with mean perfusion. Tobacco use, triglycerides, waist-to-hip ratio, and a composite risk score were not associated with perfusion. Without FDR adjustment, a relationship was also observed between perfusion and obesity, cholesterol, and fasting glucose. Neither APOE genotype nor race moderated relationships between risk factors and perfusion. Conclusion Higher diastolic blood pressure predicted lower perfusion more strongly than other cardiovascular risk factors. This relationship did not vary by racial group or genetic risk for AD, although the African American sample had greater vascular risk burden and lower perfusion rates. Our findings highlight the need to prioritize inclusion of underrepresented groups in neuroimaging studies and to continue exploring the link between modifiable risk factors, cerebrovascular health, and AD risk in underrepresented populations. |
Databáze: | OpenAIRE |
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