Neuroprotective effect of bone marrow-derived mesenchymal stem cell secretome in 6-OHDA-induced Parkinson's disease
| Autor: | D.S. Malik, Dhruv Mahendru, Uma Nahar, Ajay Prakash, Bikash Medhi, Alka Bhatia, Neha Dhir, Ashish Jain, Phulen Sarma, Shalmoli Bhattacharyya, Seema Bansal, Amit Sharma |
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| Rok vydání: | 2021 |
| Předmět: |
Embryology
Levodopa Parkinson's disease Biomedical Engineering Pharmacology medicine.disease_cause Neuroprotection Bone Marrow Animals Medicine Oxidopamine business.industry Mesenchymal stem cell Bone Marrow Stem Cell Mesenchymal Stem Cells Parkinson Disease medicine.disease Rats Disease Models Animal Neuroprotective Agents medicine.anatomical_structure Apoptosis Bone marrow business Oxidative stress medicine.drug |
| Zdroj: | Regenerative Medicine. 16:915-930 |
| ISSN: | 1746-076X 1746-0751 |
| Popis: | Aim: The aim of the study was to evaluate the neuroprotective effect of bone marrow stem cell secretome in the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. Materials & methods: Secretome prepared from mesenchymal stem cells of 3-month-old rats was injected daily for 7 days between days 7 and 14 after 6-OHDA administration. After 14 days, various neurobehavioral parameters were conducted. These behavioral parameters were further correlated with biochemical and molecular findings. Results & conclusion: Impaired neurobehavioral parameters and increased inflammatory, oxidative stress and apoptotic markers in the 6-OHDA group were significantly modulated by secretome-treated rats. In conclusion, mesenchymal stem cell-derived secretome could be further explored for the management of Parkinson's disease. |
| Databáze: | OpenAIRE |
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