SARS-COV-2 Infection in People Living with HIV: Experience from a Tertiary Hospital in Madrid

Autor: Maria, González Guembe, Yago, Tisner Pensado, Francisco, Tejerina Picado, Cristina, Diez, Leire, Pérez Latorre, Chiara, Fanciulli, Francisco, Parras Vázquez, Juan Carlos, López Bernaldo de Quirós, Juan, Berenguer, Belen, Padilla Ortega, Marina, Machado, Maricela, Valerio Minero, Patricia, Muñoz Garcia, Emilio, Bouza Santiago, Alicia, Galar, Pilar, Catalan, Roberto, Alonso, Jose M, Bellón, Teresa, Aldámiz-Echevarría Lois, And de la Villa, Sofía
Rok vydání: 2022
Předmět:
Zdroj: AIDS Research and Human Retroviruses. 38:394-398
ISSN: 1931-8405
0889-2229
DOI: 10.1089/aid.2021.0159
Popis: Since SAR-COV-2 infection emerged and spread worldwide, little is known about its impact on people living with human immunodeficiency virus (HIV). We performed a single-center retrospective study to describe the potential particularities and risk factors for respiratory failure (RF) in that population. This single-center retrospective study included patients infected with HIV, whose current follow-up is run in this center, above18 years of age, with diagnosis of SARS-CoV-2 infection between March 5, 2020 and April 15, 2021. We collected data regarding HIV immunological and virological status, main epidemiological characteristics, as well as those conditions considered to potentially influence in SARS-CoV-2 evolution; and clinical, microbiological, radiological, respiratory status, and survival concerning coronavirus disease 2019 (COVID-19). We compared all that, for patients with and without RF and performed a logistic regression for suspected risk factors for RF. One hundred seventy-seven HIV patients were diagnosed from COVID-19 (mean age 53.8 years, 81.3% male). At diagnosis, 95.5% were receiving ART and 91.3% had undetectable viral load, with median CD4 count of 569 cells/μL. One hundred thirty-eight patients (78.4%) had symptoms, 44 (25%) developed RF and 53 (31%) developed bilateral pneumonia. The most commonly used treatments were: steroids (26.7%) and hydroxychloroquine (13.1%). When comparing patients with and without RF, we found statistically significant differences for 20 of the analyzed variables such as age (
Databáze: OpenAIRE
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