The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran
| Autor: | Hossein Ayatollahi, Omolbanin Sargazi-Aval, Ali Fani, Payam Siyadat, Maryam Sheikhi, Mohammad Hadi Sadeghian, Ali Bazi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Acute promyelocytic leukemia
medicine.medical_specialty Acute myeloid leukemia Survival business.industry Medical record t(15 17)(q22 q12) Myeloid leukemia North east T-15 medicine.disease Leukemia medicine.anatomical_structure Internal medicine White blood cell Medicine Original Article Blood cancer business Survival rate |
| Zdroj: | Iranian Journal of Pathology |
| ISSN: | 2345-3656 |
| DOI: | 10.30699/ijp.2020.101417.2007 |
| Popis: | Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML). Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran. Methods: Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was obtained from archived medical records. Statistical analysis was performed by SPSS 18 software using log-ranked test and Kaplan Maier survival analysis. Results: Females and males comprised 49% and 51%, respectively. The mean age at diagnosis was 34.3±14.1 years old. During the study period, 17 demises occurred in males, while this number was 7 in females. The mean survival of patients (month) was 23.22±3.57 (95% CI: 16.21±30.2). The five-year survival rate obtained 30%. Regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count 140×109/l (100%). Conclusion: Younger age, lower WBC count and higher platelet count were significantly associated with longer survival in AML patients with t(15;17)(q22; q12). |
| Databáze: | OpenAIRE |
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