Mutant C57Bl/Kslepr(db/+) mice as a genetic model of type 2 diabetes mellitus
| Autor: | A. R. Zakir’yanov, E. A. Stepanova, T. B. Beskova, O. V. Baranova, N. A. Onischenko, O. I. Stepanova, X. X. Semenov, N. N. Karkischenko, T. V. Galahova |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases General Biochemistry Genetics and Molecular Biology Mice Atrophy Polyuria Internal medicine Diabetes mellitus Genetic model medicine Animals Pancreas business.industry Type 2 Diabetes Mellitus General Medicine medicine.disease Hypoplasia Mice Mutant Strains Mice Inbred C57BL Disease Models Animal Polyphagia Endocrinology Diabetes Mellitus Type 2 Receptors Leptin medicine.symptom business Polydipsia Spleen |
| Zdroj: | Bulletin of experimental biology and medicine. 144(6) |
| ISSN: | 0007-4888 |
| Popis: | The genetic model of diabetes mellitus was studied on mutant C57Bl/KsLepr(db/+) mice. These mice were characterized by high concentrations of glucose and glycosylated hemoglobin in the blood, polyuria, polyphagia, polydipsia, progressive obesity, biphasic morphological changes in insular islets of the pancreas (hyperplasia and atrophy), fatty degeneration of the liver, and hypoplasia of the spleen tissue and lymph nodes. Our results indicate that C57Bl/KsLepr(db/+) mice serve as an adequate model of type 2 diabetes mellitus. This model is suitable for testing of therapeutic methods for type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
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