Review; post-marketing surveillance of the safety of cimetidine-the problems of data interpretation

Autor:	D. G. Colin Jones, M. J. S. Langman, D H Lawson, Martin Vessey
Rok vydání:	2007
Předmět:	Adult Male medicine.medical_specialty High prevalence Hepatology business.industry Interpretation (philosophy) Confounding Gastroenterology Postmarketing surveillance Data interpretation Disease Middle Aged Product Surveillance Postmarketing medicine Humans Female Pharmacology (medical) Safety Cimetidine Adverse effect Intensive care medicine business medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 1:167-177
ISSN:	1365-2036 0269-2813
Popis:	SUMMARY Experience obtained during post-marketing surveillance of the safety of cimetidine emphasizes the difficulties in interpretation posed by the high background frequency of disease of all types in drug takers. The multiple sources of confounding factors, and their high prevalence, make it impossible to detect adverse events which mimic ordinary disease, particularly when a consistent relationship between adverse event and drug exposure is not observed. The inclusion of controls emphasizes the difficulties but does not ease interpretation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786168796336a5cf326f859d8119e9fa https://doi.org/10.1111/j.1365-2036.1987.tb00616.x Zobrazit plný text záznamu Plný text