Supervision of Epileptic Patients Taking Phenytoin
| Autor: | J. F. Dunne, A. J. Handley, B. L. Hazleman, F. B. Gibberd |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Adult
Male Phenytoin medicine.medical_specialty Outpatient Clinics Hospital Sodium phenytoin Epilepsy Internal medicine otorhinolaryngologic diseases Humans Medicine Medical prescription General Environmental Science business.industry General Engineering Papers and Originals General Medicine Middle Aged Serum concentration medicine.disease Response to treatment Hospitalization Anesthesia General Earth and Planetary Sciences Female business medicine.drug |
| Zdroj: | BMJ. 1:147-149 |
| ISSN: | 1468-5833 0959-8138 |
| Popis: | Serum phenytoin concentrations in outpatients and inpatients with epilepsy have been contrasted. Individual patients were receiving prescriptions ranging from 100 to 300 mg. of sodium phenytoin daily, but the two groups were comparable in respect of dosage, age, and sex distribution. Whereas the mean phenytoin concentration among 14 inpatients was 28 mug./ml. that among 15 outpatients was only 15.7 mug./ml. When the supervision of a further 12 outpatients was changed to include more frequent visits and regular provision of blood samples their mean serum concentration of phenytoin rose from 17.5 to 27.7 mug./ml.The results indicate that failure to follow dosage instructions is a factor of major importance among epileptic patients whose response to treatment is inadequate or erratic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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