Individuals with inherited chromosomally integrated human herpes virus 6 (ciHHV-6) have functionally active HHV-6 specific T-cell immunity
| Autor: | Simone Kayser, Wolfgang Schwinger, Christian Urban, Tobias Feuchtinger, Kai-Erik Witte, G. Jahn, Volker Strenger, D. Lassner |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Necrosis Herpesvirus 6 Human T-Lymphocytes Virus Integration viruses medicine.medical_treatment Roseolovirus Infections Biology medicine.disease_cause Immune tolerance Flow cytometry Young Adult 03 medical and health sciences 0302 clinical medicine medicine Chromosomes Human Humans Aged Aged 80 and over medicine.diagnostic_test virus diseases Cytomegalovirus General Medicine Middle Aged biochemical phenomena metabolism and nutrition Acquired immune system Virology 030104 developmental biology Infectious Diseases Cytokine 030220 oncology & carcinogenesis Immunology Cytokines Female medicine.symptom CD8 |
| Zdroj: | Clinical Microbiology and Infection. 22:209.e5-209.e8 |
| ISSN: | 1198-743X |
| DOI: | 10.1016/j.cmi.2015.10.006 |
| Popis: | To evaluate the human herpes virus 6 (HHV-6) -specific immune response in individuals with chromosomally integrated HHV-6 (ciHHV-6), we measured HHV-6-antigen-specific cytokine responses (interferon-γ, interleukin-2, tumour necrosis factor-α) in T cells by flow cytometry in 12 and 16 individuals with and without ciHHV-6, respectively. All individuals with ciHHV-6 showed HHV-6-specific T cells with higher frequencies of HHV-6-specific CD8(+) cells (0.03-14.93, median 2.15% of CD8(+) cells) compared with non-ciHHV-6 (0.0-10.67, median 0.36%, p 0.026). The observed increased HHV-6-specific functionally active responses in individuals with ciHHV-6 clearly disprove speculations on immune tolerance in ciHHV-6 and indicate clinical and immunological implications of ciHHV-6. |
| Databáze: | OpenAIRE |
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