HSV-1 Cytoplasmic Envelopment and Egress
| Autor: | Imran Nazir Ahmad, Duncan W. Wilson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
viruses Herpesvirus 1 Human Review Biology medicine.disease_cause Catalysis ESCRT lcsh:Chemistry Inorganic Chemistry microtubules 03 medical and health sciences Microtubule Organelle medicine Animals Humans Inner membrane Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Virus Release Spectroscopy 030102 biochemistry & molecular biology envelopment Organic Chemistry DNA replication Herpes Simplex General Medicine herpes simplex virus HSV-1 Computer Science Applications Cell biology 030104 developmental biology Herpes simplex virus lcsh:Biology (General) lcsh:QD1-999 Capsid Cytoplasm Viral Envelope Host-Pathogen Interactions sorting |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 5969, p 5969 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA replication, capsid assembly, and genome packaging take place in the infected cell nucleus, which mature nucleocapsids exit by envelopment at the inner nuclear membrane then de-envelopment into the cytoplasm. Once in the cytoplasm, capsids travel along microtubules to reach, dock, and envelope at cytoplasmic organelles. This generates mature infectious HSV-1 particles that must then be sorted to the termini of sensory neurons, or to epithelial cell junctions, for spread to uninfected cells. The focus of this review is upon our current understanding of the viral and cellular molecular machinery that enables HSV-1 to travel within infected cells during egress and to manipulate cellular organelles to construct its envelope. |
| Databáze: | OpenAIRE |
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