Biomimetic Nanostructures with Compositional Gradient Grown by Combinatorial Matrix-Assisted Pulsed Laser Evaporation for Tissue Engineering
| Autor: | Emanuel Axente, Felix Sima |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Nanostructure
Fabrication Materials science Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry law.invention Coated Materials Biocompatible Tissue engineering Biomimetics law Drug Discovery Pharmacology chemistry.chemical_classification Tissue Engineering Lasers Biomolecule Organic Chemistry 021001 nanoscience & nanotechnology Laser Evaporation (deposition) Nanostructures 0104 chemical sciences chemistry Molecular Medicine Nanomedicine Surface modification 0210 nano-technology |
| Zdroj: | Current Medicinal Chemistry. 27:903-918 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867326666190916145455 |
| Popis: | There is permanent progress with the fabrication of smart bioactive surfaces that could govern tissue regeneration. Thin coatings of two or more materials with compositional gradient allow the construction of arrays with different chemical and physical features on a solid substrate. With such intelligent bio-platforms, cells can be exposed to a tissue-like biomimetic micro-environment with precise characteristics that directs cells fate towards specific phenotypes. : We have introduced combinatorial matrix-assisted pulsed laser evaporation (C-MAPLE) as an alternative approach for the fabrication in a single-step process of either organic or inorganic thin and nanostructured coatings with variable composition. A continuous reciprocal gradient of two biomolecules can be achieved by C-MAPLE with discrete areas exhibiting physicochemical specificity that modulates intracellular signaling events. : Herein, we present a review of the current combinatorial laser strategies and methods for fabricating thin organic and inorganic films with compositional gradient with emphasis on the surface influence on cell responsiveness. In particular, the specific biological potential of surface functionalization with thin coatings of biopolymers, proteins and drugs will be discussed. Laser deposition combinatorial processes are considered an emerging unconventional technology that can be widely applied to produce composite multilayers and micro-patterns for faster cell colonization and tissue engineering. |
| Databáze: | OpenAIRE |
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