Left ventricular volumes by gated equilibrium radionuclide angiography: a new method
| Autor: | Matthias Pfisterer, D Ricci, R Kaiser, Donald G. Gordon, Joel S. Karliner, Robert A. Slutsky, Kirk L. Peterson, William L. Ashburn |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Time Factors Heart Ventricles Coronary Disease Models Biological Imaging phantom Isotopes of technetium Radionuclide angiography Physiology (medical) Technetium-99 medicine Humans Radionuclide Imaging Aged Body surface area Radionuclide medicine.diagnostic_test business.industry Heart Blood flow Middle Aged Radiography Standard error Female Cardiology and Cardiovascular Medicine Nuclear medicine business |
| Zdroj: | Circulation. 60:556-564 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | To compare radionuclide end-diastolic (EDV) and end-systolic (ESV) volumes with angiographic volume, we studied 52 patients with equilibrium radionuclide angiography using 99mTc-human serum albumin within 48 hours of contrast angiography. Each RR interval was divided into 20--28 equally timed frames and a time-activity curve generated. End-diastolic counts were taken at the early peak of the curve and end-systolic counts at its nadir. Counts were divided by the total number of processed heart beats and normalized for: 1) dose per body surface area; 2) plasma volume; and 3) counts/ml of plasma. A cardiac phantom was developed and serial volumes were studied using a normalization factor. Radionuclide values were expressed as dimensionless units and compared with either biplane angiographic volumes (in the patient studies) or known phantom volumes. Good correlations were obtained with methods 1 and 2 in 35 patients (r greater than 0.84), but the best correlation was obtained in 17 patients when normalization for counts/ml of plasma was used (r = 0.98; y = 0.255 x -0.121). The standard error of the estimate (SEE) was +/- 11.5 ml for EDV and +/- 7.3 ml for ESV. The phantom study also showed an excellent correlation (r = 0.99), with a SEE of +/- 6.5 ml. We conclude that a radionuclide method independent of geometric assumptions can be used to estimate left ventricular volume in man. |
| Databáze: | OpenAIRE |
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