Glutathione-peroxidase and glutathione-reductase activities of normal and pathologic human liver: relationship with age
| Autor: | Roberto Corrocher, O. Miatto, G.B. Gabrielli, M Casaril, G. De Sandre, C Guidi |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular G protein Glutathione reductase Biology Liver disease Internal medicine medicine Carcinoma Humans Aged chemistry.chemical_classification Glutathione Peroxidase Glutathione peroxidase Liver Diseases Liver Neoplasms Gastroenterology Age Factors Cancer Middle Aged medicine.disease Endocrinology Enzyme Glutathione Reductase chemistry Liver Peroxidases Female |
| Zdroj: | Scandinavian journal of gastroenterology. 15(7) |
| ISSN: | 0036-5521 |
| Popis: | Liver glutathione-peroxidase (L-GSH-Px) and glutathione-reductase (GSSG-Red) activities were measured in supernatants of liver tissues obtained from a total of 36 subjects. Sixteen of these patients had a functionally normal liver (control group), whereas of the remaining 20 patients, 10 were cirrhotic and 10 had a liver disease other than cirrhosis. The mean value of L-GSH-Px of the control group was 33.12 +/- 12.66 U/g protein, a value similar to that found in patients with liver disease. The L-GSH-Px of the control group was positively correlated with the age of the subjects (r = 0.620; p less than 0.02). In contrast, in patients with liver disease an opposite behaviour of the two parameters was noted (r = -0.497; p less than 0.05). L-GSH-Px activity tended to be higher in males than in females, whereas the erythrocyte glutathione-peroxidase (E-GSH-Px) of the same patients was higher in females, albeit not significantly. L-GSH-Px and E-GSH-Px were not correlated either in normal or in liver disease. The mean GSSG-Red of the control group was 40.63 +/- 11.10 U/g protein, which is not different from that of the group of liver patients. GSSG-Red was not correlated with L-GSH-Px or with the age of patients. In two patients with hepatoma, the GSH-Px activity of the cancer tissue was low and the GSSG-Red activity high. |
| Databáze: | OpenAIRE |
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