The Prenatal Expression of Secretin Receptor
| Autor: | Mai Har Sham, Francis K.Y. Siu, Billy K. C. Chow |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Central Nervous System
medicine.medical_specialty Central nervous system In situ hybridization Biology digestive system General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone Secretin Mice fluids and secretions History and Philosophy of Science Internal medicine medicine Animals In Situ Hybridization General Neuroscience Embryogenesis Gene Expression Regulation Developmental Embryo digestive system diseases medicine.anatomical_structure Endocrinology Secretin receptor Choroid plexus Duct (anatomy) hormones hormone substitutes and hormone antagonists |
| Zdroj: | Annals of the New York Academy of Sciences. 1070:561-565 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1317.081 |
| Popis: | Secretin is a classical gastrointestinal peptide while its neuroactive functions in the central nervous system have recently been consolidated. In the past, there was little information regarding the expression of secretin receptor in prenatal development. In this article, using mouse embryos and by in situ hybridization, secretin receptor transcripts were detected in several developing brain regions including the cerebellar primordium and choroid plexus. In the developing intestine, secretin receptor is present in the epithelial lining of the villi and the inner circular muscle. Interestingly, the transcripts for secretin receptor were also detected in the epicardium and myocardium of the developing heart as well as the glomerulus and collecting duct in the developing kidney. Taken together, our data suggest a potential pleiotrophic role of secretin during embryonic development. |
| Databáze: | OpenAIRE |
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