Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin
| Autor: | N. K. Nurmuradov, Ya. A. Andreev, Elena Kalinina, Albina S. Petrova, Alexander A. Shtil, K. I. Lubova, Maria Novichkova, N. N. Chernov |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gene isoform GPX1 NF-E2-Related Factor 2 Antineoplastic Agents Drug resistance General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Glutathione Peroxidase GPX1 Cell Line Tumor Gene expression medicine Homeostasis Humans Transcription factor Cisplatin chemistry.chemical_classification Glutathione Peroxidase NADPH oxidase biology Superoxide Dismutase Ovary General Medicine Catalase Cell biology Gene Expression Regulation Neoplastic 030104 developmental biology Enzyme chemistry NADPH Oxidase 5 Drug Resistance Neoplasm 030220 oncology & carcinogenesis biology.protein Female Oxidation-Reduction Heme Oxygenase-1 medicine.drug Signal Transduction |
| Zdroj: | Bulletin of experimental biology and medicine. 165(5) |
| ISSN: | 1573-8221 |
| Popis: | Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2, as well as reduced expression of the gene encoding NOX5 isoform of NADPH oxidase. The results testify to redox-dependent development of the adaptive antioxidant response as an important process in the mechanism of formation of resistance to cisplatin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink