α-cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents

Autor:	Roel P L, Bell, Dennis, Verdijk, Mike, Relou, Dennis, Smith, Henk, Regeling, Eelco J, Ebbers, Frank M C, Leemhuis, Daniela C, Oniciu, Clay T, Cramer, Brian, Goetz, Michael E, Pape, Brian R, Krause, Charles L, Bisgaier, Jean-Louis, Dasseux
Rok vydání:	2005
Předmět:	Male Magnetic Resonance Spectroscopy Ketone Stereochemistry Lipoproteins Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Mass Spectrometry Rats Sprague-Dawley chemistry.chemical_compound In vivo Drug Discovery medicine Animals Dicarboxylic Acids Molecular Biology Cells Cultured chemistry.chemical_classification Organic Chemistry TosMIC Biological activity Lipids Rats medicine.anatomical_structure Dicarboxylic acid Mechanism of action chemistry Hepatocyte Hepatocytes Molecular Medicine medicine.symptom
Zdroj:	Bioorganic & Medicinal Chemistry. 13:223-236
ISSN:	0968-0896
DOI:	10.1016/j.bmc.2004.09.046
Popis:	A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on the de novo incorporation of radiolabeled acetate into lipids in primary cultures of rat hepatocytes, and they showed lipid-regulating properties when tested in vivo in female obese Zucker fatty rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78510470ed7f346fd296d9349082a003 https://doi.org/10.1016/j.bmc.2004.09.046 Zobrazit plný text záznamu Full Text from ScienceDirect