Troponin T levels associated with genetic variants in NOTCH2 and MTNR1B in women with psychosis

Autor:	David Erlinge, Martin Schalling, Urban Ösby, Dzana Sudic Hukic, Claes-Göran Östenson, Eric Olsson, Catharina Lavebratt, Sven V. Eriksson
Rok vydání:	2016
Předmět:	0301 basic medicine Adult Blood Glucose Male Psychosis medicine.medical_specialty macromolecular substances Type 2 diabetes Disease 030204 cardiovascular system & hematology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Troponin T Risk Factors Internal medicine medicine Humans Receptor Notch2 Biological Psychiatry Aged Aged 80 and over biology business.industry Receptor Melatonin MT2 Genetic variants Genetic Variation Glucose Tolerance Test Middle Aged musculoskeletal system medicine.disease Troponin Psychiatry and Mental health 030104 developmental biology Endocrinology Cross-Sectional Studies Glucose Psychotic Disorders Schizophrenia biology.protein Biomarker (medicine) Female business
Zdroj:	Psychiatry research. 250
ISSN:	1872-7123
Popis:	Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2 rs10923931 associated with troponin T levels in women, adjusted for glucose levels. These findings may indicate metabolic genetic influences on troponin T levels among women with psychosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78501df71d959792516fd0ea20416e57 https://pubmed.ncbi.nlm.nih.gov/28167435 Zobrazit plný text záznamu Full Text from ScienceDirect