Prohedonic properties of gamma-hydroxybutyrate are associated with changes in limbic resting-state functional connectivity
| Autor: | Dario Dornbierer, Robin von Rotz, Rainer Kraehenmann, Fabrizio Esposito, Philipp Staempfli, Oliver G. Bosch, Erich Seifritz, Boris B. Quednow |
|---|---|
| Přispěvatelé: | University of Zurich, Bosch, Oliver G, Bosch, O. G., Esposito, F., Dornbierer, D., von Rotz, R., Kraehenmann, R., Staempfli, P., Quednow, B. B., Seifritz, E. |
| Rok vydání: | 2018 |
| Předmět: |
Male
libido Euphoriant 2738 Psychiatry and Mental Health 0302 clinical medicine Limbic System 2736 Pharmacology (medical) Medicine Pharmacology (medical) 10064 Neuroscience Center Zurich Cerebral Cortex Cross-Over Studies Cross-Over Studie Euphoria Magnetic Resonance Imaging anhedonia Psychiatry and Mental health 2728 Neurology (clinical) medicine.anatomical_structure Neurology medicine.symptom sodium oxybate Human Adult medicine.medical_specialty Clinical Neurology 610 Medicine & health Gyrus Cinguli Young Adult 03 medical and health sciences mania Double-Blind Method liquid ecstasy Internal medicine Connectome Humans Paracentral lobule Anterior cingulate cortex Resting state fMRI business.industry Anhedonia Gamma hydroxybutyrate GABA-B Receptor Agonist 030227 psychiatry Endocrinology nervous system Superior frontal gyrus 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics 2808 Neurology GABA-B Receptor Agonists Neurology (clinical) business Insula 030217 neurology & neurosurgery |
| Zdroj: | Human Psychopharmacology: Clinical and Experimental. 33:e2679 |
| ISSN: | 0885-6222 |
| DOI: | 10.1002/hup.2679 |
| Popis: | Objective: Gamma-hydroxybutyrate (GHB) is an endogenous GHB-/GABA-B receptor agonist and a narcolepsy treatment. However, GHB is also abused for its prohedonic effects. On a neuronal level, it was shown that GHB increases regional cerebral blood flow in limbic areas such as the right anterior insula (rAI) and the anterior cingulate cortex (ACC). We aimed to further explore the association between the subjective and neuronal signatures of GHB. Method: We assessed subjective effects and resting-state functional connectivity (rsFC) of an rAI- and an ACC-seed in 19 healthy male subjects after GHB (35mg/kg p.o.) using a placebo-controlled, double-blind, randomized, cross-over functional magnet resonance imaging design. Results: GHB increased subjective ratings for euphoria (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|