A new antifungal coumarin from Clausena excavata
| Autor: | Dipanwita Saha, Ramashish Kumar, Aniruddha Saha |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Nystatin
Antifungal Agents Clausena excavata Microbiology Rhizoctonia solani Candida tropicalis Clausena Coumarins Drug Discovery Fusarium oxysporum Pharmacology Molecular Structure biology Plant Extracts Sclerotinia sclerotiorum Fungi food and beverages General Medicine biology.organism_classification Fungicides Industrial Plant Leaves Mucor circinelloides Benzimidazoles Carbamates Lasiodiplodia theobromae |
| Zdroj: | Fitoterapia. 83:230-233 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2011.11.003 |
| Popis: | A new γ-lactone coumarin, named as excavarin-A, showing antifungal activity was isolated from the leaves of Clausena excavata by bioassay guided fractionation method. The structure was elucidated by spectroscopic data analysis and identified as 7((2E)-4(4,5-dihydro-3-methylene-2-oxo-5-furanyl)-3-methylbut-2-enyloxy) coumarin. Minimum inhibitory concentration (MIC) was determined against fifteen fungal strains pathogenic against plants and human. The least MIC was recorded against the human pathogen, Candida tropicalis and the plant pathogens Rhizoctonia solani and Sclerotinia sclerotiorum. Antifungal activities against the human pathogens, Aspergillus fumigatus and Mucor circinelloides and plant pathogens, Colletotrichum gloeosporioides, Lasiodiplodia theobromae, Fusarium oxysporum and Rhizopus stolonifer were stronger than that of the standard antimicrobials. |
| Databáze: | OpenAIRE |
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