CD4 Count Recovery After Initiation of Antiretroviral Therapy in Patients Infected With Human Immunodeficiency Virus
| Autor: | Sarah C. DeShields, Stephanie B. Troy, Johnathon Drake Bishop, Tina D. Cunningham |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male 0301 basic medicine medicine.medical_specialty Multivariate analysis Art initiation 030106 microbiology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Antiretroviral Therapy Highly Active Internal medicine medicine Electronic Health Records Humans In patient 030212 general & internal medicine business.industry General Medicine Viral Load Antiretroviral therapy CD4 Lymphocyte Count Anti-Retroviral Agents Baseline weight Immunology Female Analysis of variance business Viral load |
| Zdroj: | The American Journal of the Medical Sciences. 352:239-244 |
| ISSN: | 0002-9629 |
| Popis: | Background Prognosis for patients infected with human immunodeficiency virus (HIV) correlates with levels of CD4+ T cells. Initiation of antiretroviral therapy (ART) interrupts multiple points in the virus life cycle, causing an increase in CD4 cells. The rate at which the CD4 count recovers is highly variable and subject to influence by many factors. Methods We performed a deidentified data review to determine factors influencing the rate of CD4 count recovery after ART initiation. The associations between the changes in CD4 count from baseline at 5 time points, and factors including age, race, weight, baseline CD4 count, baseline viral load, specific ART medications and various comorbidities, were evaluated with univariate and multivariate analyses, using t -test, analysis of variance and multiple regressions. Results CD4 count continued to rise even up to 10 years after ART initiation, with the steepest increase in the first 3 months. High baseline viral load and low baseline CD4 count had the most consistent positive influence on CD4 count recovery rate across the 5 measured time points. Other factors that were significantly positively associated with CD4 recovery rate included younger baseline age, higher baseline weight and female gender. Conclusions CD4 counts in HIV positive patients who consistently take ART continue to increase out to at least 10 years. Patients with a more advanced HIV infection at baseline, as indicated by high viral loads or low CD4 counts, have a greater rate of CD4 count recovery after starting ART, possibly because their CD4 counts have more room for improvement. |
| Databáze: | OpenAIRE |
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