Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome
Autor: | Nicoline Hoogerbrugge, Angèle L.M. Oei, Lotte H. M. Gerritzen, Maaike A.P.C. van Ham, Fokko M. Nagengast, Joanne A. de Hullu, Leon F.A.G. Massuger |
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Rok vydání: | 2009 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty Amsterdam criteria Genetics and epigenetic pathways of disease [NCMLS 6] Biopsy medicine.medical_treatment HNPCC Aetiology screening and detection [ONCOL 5] Endometrial carcinoma Article Endometrial sampling Atypical hyperplasia Quality of Care [ONCOL 4] Endosonography Molecular epidemiology [NCEBP 1] Young Adult Translational research [ONCOL 3] Ovarian carcinoma Genetics medicine Carcinoma Humans Mass Screening Genetic Predisposition to Disease Genetics(clinical) Genetics (clinical) Mass screening Aged Ovarian Neoplasms Gynecology Surveillance Hysterectomy Hereditary cancer and cancer-related syndromes [ONCOL 1] medicine.diagnostic_test business.industry Middle Aged medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Lynch syndrome Endometrial Neoplasms Oncology Population Surveillance Screening Female business Endometrial biopsy |
Zdroj: | Familial Cancer, 8, 391-7 Familial Cancer Familial Cancer, 8, 4, pp. 391-7 |
ISSN: | 1573-7292 1389-9600 |
Popis: | Contains fulltext : 80311.pdf (Publisher’s version ) (Closed access) In women with hereditary non polyposis colorectal carcinoma (HNPCC) an annual gynaecological surveillance has been recommended because of an increased lifetime risk of developing endometrial and ovarian carcinoma. The aim of this study was to assess the efficacy of gynaecological surveillance with regard to endometrial and ovarian carcinoma. Included were women from families that fulfilled the revised Amsterdam criteria for HNPCC or who showed a proven mutation in one of the mismatch repair genes. An annual gynaecological surveillance was performed (transvaginal ultrasound (TVU) and CA 125 assessment). From January 2006 on, routine endometrial sampling was included. In a total number of 100 women 285 surveillance visits were performed. Among these, in 64 visits routine endometrial samplings were performed: three atypical hyperplasias and one endometrial carcinoma were diagnosed. This was significantly more than the atypical hyperplasia and two endometrial carcinomas that were detected after 28 samples performed because of abnormal surveillance results in 221 visits. There were no interval carcinomas. One invasive ovarian carcinoma stage IIIC was diagnosed at ovarian surveillance. Endometrial surveillance with routine endometrial sampling in women with HNPCC is more efficient in diagnosing endometrial (pre)malignancies than TVU only. Ovarian surveillance is not capable of diagnosing early stage ovarian carcinoma. Prophylactic hysterectomy in HNPCC should be restricted to women in whom abdominal surgery for other reasons is performed and to those with particularly increased risk such as MSH6 mutation carriers and/or women with multiple relatives with endometrial carcinoma. |
Databáze: | OpenAIRE |
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