Time Course of Conjunctival Hyperemia Induced by a Rho-kinase Inhibitor Anti-glaucoma Eye Drop: Ripasudil 0.4
| Autor: | Atsuki Fukushima, Tsuyoshi Yoneda, Yasuko Fujisawa, Kanae Matsuya, Yui Kobayashi, Shunsuke Nakakura, Yuki Fujio, Hitoshi Tabuchi, Etsuko Terao, Yoshiaki Kiuchi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Intraocular pressure genetic structures medicine.medical_treatment Glaucoma Hyperemia Severity of Illness Index Conjunctival Diseases 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Young Adult 0302 clinical medicine Ophthalmology medicine Humans Conjunctival hyperemia Intraocular Pressure Sulfonamides rho-Associated Kinases Slit lamp business.industry Eye drop Middle Aged medicine.disease Isoquinolines eye diseases Sensory Systems Healthy Volunteers Surgery body regions 030104 developmental biology chemistry Rho kinase inhibitor Time course cardiovascular system 030221 ophthalmology & optometry Female sense organs Ripasudil Ophthalmic Solutions business Conjunctiva |
| Zdroj: | Current eye research. 42(5) |
| ISSN: | 1460-2202 |
| Popis: | We investigated the detailed time course of conjunctival hyperemia induced by ripasudil 0.4%, a novel Rho-kinase inhibitor anti-glaucoma eye drop, in healthy subjects.We recruited 51 healthy subjects and administered ripasudil 0.4% in their right eye. We evaluated conjunctival hyperemia using slit lamp photography and measured the intraocular pressure (IOP) using the Icare PRO Rebound Tonometer at baseline and after 5, 15, 30, 60, 90, and 120 min. The conjunctival hyperemia score was graded by three independent observers on a scale of 0 (none) to 3 (severe). Additionally, we analyzed the "percent coverage" of conjunctival hyperemia by using an automated hyperemia analysis software program; this program provides the pixel coverage of the conjunctival vessels in the region of interest. Dunnett and Steel multiple comparison tests were used, as appropriate, for the subsequent analyses.The conjunctival hyperemia score and percent coverage increased rapidly after the instillation of ripasudil 0.4%, peaking at 15 min (score: 1.83 ± 0.29 [mean ± SD]) and 5 min (11.6% ± 4.7%), respectively, and then gradually decreasing until 120 min (0.45 ± 0.22 and 4.7% ± 1.8%, respectively), when they reached a level that was not significantly different from the baseline values. The IOP decreased significantly compared to the baseline at 30, 60, and 90 min, based on the Dunnett test.Conjunctival hyperemia induced by ripasudil 0.4% peaks rapidly to moderate severity, but subsides relatively quickly. |
| Databáze: | OpenAIRE |
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