Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis
| Autor: | Xiaomin Cai, Lingyan Xu, Shuhui Si, Haiwei Yang, Peinan Lin, Xiao Han, Yanhong Gu, Feng Wang, Zhiqiang Qin, Lele Li |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Funnel plot gene polymorphism Population Biophysics colorectal cancer Polymorphism Single Nucleotide Biochemistry 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Internal medicine Genotype medicine Humans Genetic Predisposition to Disease education Molecular Biology Genetic Association Studies Methylenetetrahydrofolate Reductase (NADPH2) Research Articles education.field_of_study biology business.industry Cell Biology Publication bias Odds ratio meta-analysis 030104 developmental biology 030220 oncology & carcinogenesis Methylenetetrahydrofolate reductase Meta-analysis MTHFR biology.protein Gene polymorphism Colorectal Neoplasms business Research Article |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer (CRC) susceptibility has been researched in numerous studies. However, the results of these studies were controversial. Therefore, the objective of this meta-analysis was to offer a more convincible conclusion about such association with more included studies. Eligible studies published till May 1, 2017 were searched from PubMed, Embase, Web of Science, and CNKI database about such association. Pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated to evaluate such association. And the Begg’s funnel plot and Egger’s test were applied to assess the publication bias. This meta-analysis contained 37049 cases and 52444 controls from 87 publications with 91 eligible case–control studies. Because of lack of data for a particular genotype in several studies, all the included studies were analysed barely in the dominant model. Originally, there was no association between MTHFR C677T polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94–1.05). After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94–0.99). In the subgroup analysis of ethnicity, there was a significant association in Asians (OR =0.94, 95% CI =0.89–1.00). Furthermore, when stratified by the source of controls and genotyping methods, the positive results were observed in population-based control group (OR =0.97, 95% CI =0.93–1.00) and PCR-restriction fragment length polymorphism (PCR-RFLP) method (OR =0.95, 95% CI =0.91–0.99. The results of the meta-analysis suggested that MTHFR C677T polymorphism was associated with CRC susceptibility, especially in Asian population. |
| Databáze: | OpenAIRE |
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