Technical Feasibility and Design of a Shape Memory Alloy Support Device to Increase Ejection Fraction in Patients with Heart Failure

Autor: Salah A.M. Saïd, Jan G. Grandjean, K. M. Aarnink, Jos M. J. Paulusse, F.R. Halfwerk
Přispěvatelé: Biomolecular Nanotechnology
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Models
Anatomic
medicine.medical_specialty
Ejection fraction
Time Factors
medicine.medical_treatment
0206 medical engineering
Biomedical Engineering
Cardiac resynchronization therapy
UT-Hybrid-D
Heart failure
02 engineering and technology
030204 cardiovascular system & hematology
Prosthesis Design
Ventricular Function
Left
Article
Shape memory alloy
law.invention
03 medical and health sciences
0302 clinical medicine
law
Internal medicine
Design configuration
Medicine
Humans
Spiral
business.industry
Pulse (signal processing)
Models
Cardiovascular
Temperature
Stroke Volume
SMA
medicine.disease
020601 biomedical engineering
Shape Memory Alloys
Duty cycle
Ventilation (architecture)
Cardiology
Feasibility Studies
Heart-Assist Devices
Cardiology and Cardiovascular Medicine
business
Cardiac support device
Zdroj: Cardiovascular engineering and technology, 10(1), 1-9. Springer
Cardiovascular Engineering and Technology
Cardiovascular Engineering and Technology, 10(1), 1-9. SPRINGER
ISSN: 1869-4098
1869-408X
DOI: 10.1007/s13239-018-00399-7
Popis: Purpose Heart failure is increasingly prevalent in the elderly. Treatment of patients with heart failure aims at improving their clinical condition, quality of life, prevent hospital (re)admissions and reduce mortality. Unfortunately, only a select group of heart failure patients with reduced ejection fraction are eligible for Cardiac Resynchronization Therapy where 30–40% remain non-responders and need left ventricular support. The aim of this study is to investigate if a shape memory alloy (SMA) is able to increase the ejection fraction of a mono-chamber static heart model by 5%. Methods A pediatric ventilation balloon was used as a heart model (mono-chamber). Flexinol®, a SMA, was placed around the heart model in multiple configurations and activated using pulse width modulation techniques to determine influence of diameter and configuration on volume displacement. Furthermore, pressure within the heart model was measured with a custom-made pressure sensor. Results SMA with a diameter of 0.38 mm, placed in a spiral shape and activated with a duty cycle of 80% and a frequency of 50/min gave the highest ejection fraction increase of 3.5%. Conclusions This study demonstrated the feasibility of volume displacement in a static heart model by activation of SMA-wires. Configuration, duty cycle, frequency, pulse intervals and diameter were identified as important factors affecting the activation of SMA-wires on volume displacement. Future research should include the use of parallel SMA-wires, prototype testing in dynamic or ex vivo bench models. Electronic supplementary material The online version of this article (10.1007/s13239-018-00399-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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